Prader-Willi Syndrome (PWS) is a genetic disorder, with hypotonia being the predominant element in infancy, and developmental delay, obesity, and behavioral problems getting progressively conspicuous in youth and pre-adulthood. Children with this disorder frequently suffer from excessive daytime sleepiness and have a primary abnormality of the circadian rhythm of rapid eye movement sleep. They likewise have essential strange ventilatory reactions to hypoxia and hypercapnia, and these variations from the norm might be exacerbated by heftiness. Children with Prader-Willi syndrome are in danger of an assortment of variations from the norm of breathing during sleep, including obstructive sleep apnea and sleep related alveolar hypoventilation. Clinical evaluation should incorporate a cautious history of sleep related side effects and appraisal of the upper aviation route and lung work. Polysomnography ought to be considered for those with manifestations suggestive of sleep-disordered breathing. Treatment alternatives rely upon the basic issue, but may include behavioral interventions, weight control, adenotonsillectomy, and nocturnal ventilation.