In order to understand the differences between sexes in lung cancer presentation and due to the observation that young women have worse prognosis, we studied the participation of estrogens in lung carcinogenesis. We found that estradiol increases the expression of CXCR4 and promotes the activation of the CXCL12/CXCR4 axis, an important chemokine pathway involved in lung carcinogenesis and tumor progression.
Vianey Rodriguez Lara
All Published work is licensed under a Creative Commons Attribution 4.0 International License
Copyright © 2017 All rights reserved. iMedPub Last revised : December 15, 2017